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18F-Fluciclovine Uptake in Celiac Ganglia

A Pitfall in Prostate Cancer PET Imaging

Wo, Sean MD; Matesan, Manuela Cristina MD, PhD

doi: 10.1097/RLU.0000000000002693
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We present 4 cases of patients who underwent 18F-fluciclovine PET for prostate cancer demonstrating physiologic uptake in the celiac ganglia, which could be mistaken for metastatic lymphadenopathy if the celiac ganglia have a nodular configuration and uptake higher than bone marrow. Uptake in celiac, cervical, and sacral ganglia has been reported previously as an important pitfall in 68Ga-PSMA-HBED-CC PET for prostate cancer. In our patients, only celiac ganglion uptake was visualized. Advances in PET scanner technology may cause physiologic uptake of 18F-fluciclovine in celiac ganglia to become more visually distinguishable from muscular uptake in adjacent diaphragmatic crura.

From the Department of Radiology, University of Washington, Seattle, WA.

Received for publication February 13, 2019; revision accepted May 19, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Sean Wo, MD, Department of Radiology, University of Washington, 1959 NE Pacific St, Box 357115, Seattle, WA 98195. E-mail:

Online date: July 8, 2019

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