We report the case of a 23-year-old man presenting a right hypersecreting pheochromocytoma, falsely negative on 18F-FDG PET/CT and on 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy but strongly positive on 18F-FDOPA PET/CT. Functional imaging has a key role in diagnosis and prognosis of pheochromocytomas, but choosing the most relevant modality remains difficult. Despite its high specificity, 123I-MIBG has a limited sensitivity. 18F-FDG can be used, but it is an unspecific tracer, and 18F-FDG uptake in brown adipose tissue can hinder the analysis. However, 18F-FDOPA shows very high sensitivity and specificity in pheochromocytomas with fewer drug interferences than 123I-MIBG.
From the *Department of Endocrinology, l'Institut du Thorax, CHU de Nantes, Hôpital Nord
†CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes
Departments of ‡Digestive and Endocrine Surgery
§Nuclear Medicine, CHU de Nantes, Hôtel-Dieu, Nantes, France.
Received for publication February 8, 2019; revision accepted June 2, 2019.
Conflicts of interest and sources of funding: none declared.
This work has been supported in part by a grant from the French National Agency for Research called “Investissements d'Avenir” Labex IRON n°ANR-11-LABX-0018-01.
Correspondence to: Alexandre Lugat, MD, Department of Endocrinology, l'Institut du Thorax, CHU de Nantes, Hôpital Nord, 44093 Nantes Cx 01, France. E-mail: firstname.lastname@example.org.
Online date: July 15, 2019