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Incidental Detection of a Radiation-Induced Soft-Tissue Sarcoma on 68Ga-PSMA PET/CT in a Patient Previously Treated for Prostate Cancer

Plouznikoff, Nicolas MD, PhD, FRCPC*,†; Woff, Erwin MD*; Artigas, Carlos MD*; Alexiou, Jean MD; Flamen, Patrick MD, PhD*

doi: 10.1097/RLU.0000000000002592
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Radiation-induced sarcoma is a rare complication of radiation therapy. We describe the incidental detection of a radiation-induced undifferentiated soft-tissue sarcoma with increased uptake on 68Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT in a prostate cancer patient previously treated with surgery and external-beam radiotherapy. Results were confirmed by histological analysis. 68Ga-PSMA is known to bind not only to PSMA-expressing prostate cancer cells but also to the neovasculature of various other solid tumors. A careful 68Ga-PSMA PET/CT review of previously irradiated areas is warranted so as not to miss radiation-induced sarcoma in prostate cancer patients.

From the *Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium

Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada

Department of Radiology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Received for publication February 26, 2019; revision accepted March 11, 2019.

Contributions: N.P. read the PET/CT and drafted the manuscript. E.W. presented the case to the sarcoma tumor board and revised the manuscript. C.A. acted as an expert consultant for the case and revised the manuscript. J.A. read the MRI, performed the CT-guided biopsy, and revised the manuscript. P.F. revised the manuscript for important intellectual content.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Nicolas Plouznikoff, MD, PhD, FRCPC, Service de Médecine Nucléaire, Centre Hospitalier de l'Université de Montréal (CHUM), 1051 rue Sanguinet, Montréal, QC, H2X 0C1, Canada. E-mail:

Online date: April 15, 2019

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