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A Comparison of Angiogenesis and Glycolytic Imaging in Patients With Clinical Suspected Locally Advanced Breast Cancer

Vatsa, Rakhee PhD*; Ashwathanarayana, Abhiram Gopalajois MD*; Singh, Gurpreet MD; Kavanal, Anwin Joseph MBBS*; Kumar, Sunil MD*; Rana, Nivedita PhD*; Shukla, Jaya PhD*; Mittal, Bhagwant Rai MD*

doi: 10.1097/RLU.0000000000002647
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18F-FDG PET/CT imaging is an important diagnostic tool for accurate staging and assessment of response to neoadjuvant chemotherapy (NACT) in patients with locally advanced breast carcinoma (LABC). However, 18F-FDG being non-specific marker, it also accumulates in inflammatory conditions, leading to false positive results. Angiogenesis, an essential characteristic for tumor development, intrusion and metastasis can be imaged using 68Ga-labeled RGD tripeptide. We here depict a series of clinically staged LABC patients who underwent both 68Ga-DOTA-RGD2 and 18F-FDG PET/CT imaging for staging and illustrate the similarities and significant differences between the two tracers.

From the *Department of Nuclear Medicine,

General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Received for publication January 14, 2019; revision accepted April 22, 2019.

Conflicts of interest and sources of fundings: none declared.

Correspondence to: Bhagwant Rai Mittal, Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. E-mail:

Online date: June 3, 2019

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