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Pittsburgh Compound-B Uptake in Meningioma With Histopathologic Correlation

Doi, Shuhei, MD*; Kashiwagi, Nobuo, PhD*; Satou, Takao, PhD; Kaida, Hayato, PhD*; Ishi, Kazunari, PhD*

doi: 10.1097/RLU.0000000000002590
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Previous studies have reported increased Pittsburgh compound-B (PiB) uptake in meningiomas; however, histological correlation to elucidate the underlying mechanism has not yet been done. We report a case of an 82-year-old woman with an incidental intracranial tumor that showed focal increased PiB uptake. Because of tumor growth, surgical resection was performed, yielding a histological diagnosis of meningioma. Any special and immunochemical staining for amyloid did not reveal amyloid deposition in the tumor. Our findings suggest that increased PiB uptake was not associated with amyloid in this instance.

From the Departments of *Radiology and

Pathology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.

Received for publication January 10, 2019; revision accepted March 7, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Nobuo Kashiwagi, PhD, Department of Radiology, Kindai University Faculty of Medicine, 377–2 Ohno-Higashi, Osakasayama City, Osaka 589–8511, Japan. E-mail:

Online date: May 30, 2019

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