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Multifocal Meningiomas Mimicking Dural-Based Intracranial Metastases at 18F-Fluciclovine PET/CT

Manganaro, Mark S., BS*; Millet, John D., MD, MHS; Manganaro, Matthew S., MD†‡

doi: 10.1097/RLU.0000000000002629
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A 78-year-old man with biochemically recurrent prostate adenocarcinoma (prostate-specific antigen, 2.3 ng/mL) but without detectable disease in the chest, abdomen, or pelvis at conventional CT imaging or in the bones at 99mTc-MDP scintigraphy underwent 18F-fluciclovine (anti–1-amino-3-18F-fluorocyclobutane-1-carboxylic acid) PET/CT to evaluate for occult recurrent or metastatic disease. Imaging identified intense radiotracer uptake within 3 dural-based lesions along the left cerebral convexity. Subsequent MRI and biopsy confirmed multifocal World Health Organization grade 2 atypical meningiomas. Focal intracranial radiotracer uptake at 18F-fluciclovine PET/CT may create a diagnostic dilemma as incidental meningiomas can mimic intracranial metastases.

From the *Lake Erie College of Osteopathic Medicine, Erie, PA;

Department of Radiology, Michigan Medicine; and

Department of Nuclear Medicine, VA Ann Arbor Healthcare, Ann Arbor, MI.

Received for publication January 17, 2019; revision accepted April 7, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Matthew S. Manganaro, MD, Department of Radiology, Michigan Medicine, B1G 505G University Hospital, 1500 E Medical Center Dr, Ann Arbor, MI 48109–0028. E-mail:

Online date: May 17, 2019

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