We report a case of Gayet-Wernicke encephalopathy, revealed by an 18F-FDG PET/MRI performed in a patient with memory impairment. Metabolism showed no pattern of neurodegenerative disease, but a severe decrease in hippocampus and mammillary bodies (MBs). MRI images analyzed in light of PET findings revealed MB atrophy coupled with signal-intensity alterations, suggestive of a Gayet-Wernicke encephalopathy. Patient was known for alcohol use disorders, and all previous MRI scans were considered as inconclusive. Symptoms improved with correction of thiamine (vitamin B1) deficiency. This report highlights ability of hybrid PET/MRI to investigate small neuronal structures, such as the MBs involved in Gayet-Wernicke disease.
From the *Department of Nuclear Medicine, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris, Sorbonne Université;
†Laboratoire d'Imagerie Biomédicale, INSERM, CNRS, Sorbonne Université;
‡APHP, Hôptal Pitié-Salpêtrière, Médecine Nucléaire;
§Department of Functional and Diagnostic Neuroradiology, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris, Sorbonne Université; and
∥Department of Psychiatry and Neurosciences, GHU Paris Saint-Anne, Paris France.
Received for publication January 31, 2019; revision accepted March 21, 2019.
Conflicts of interest and sources of funding: none declared.
Correspondence to: Laura Rozenblum, MD, Department of Nuclear Medicine, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, 47-83 Blvd de l'Hôpital, 75013 Paris. E-mail: Laura.firstname.lastname@example.org.
Online date: May 3, 2019