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A Rare Case of Primary Endometrial Hepatoid Adenocarcinoma on 18F-FDG PET/CT

Yin, Hongyan, MD*; Hu, Yan, MD*; Xiu, Yan, MD, PhD*; Luo, Rongkui, MD; Shi, Hongcheng, MD, PhD*

doi: 10.1097/RLU.0000000000002538
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Primary endometrial hepatoid adenocarcinoma is a rare tumor. We present a case of a 64-year-old woman with vaginal bleeding for 2 months and a markedly elevated serum α-fetoprotein of 3931 ng/mL. Hysteroscopic segmental curettage revealed endometrial adenocarcinoma. A pelvic MRI was performed for local tumor invasion, which showed only endometrial mass. An abdominal enhanced CT showed no liver lesion, which excluded primary hepatic carcinoma. Staging 18F-FDG PET/CT demonstrated a hypermetabolic mass in the endometrium. A total hysterectomy with bilateral salpingo-oophorectomy and regional lymphadenectomy were performed. Postoperatively, the mass was diagnosed as primary endometrial hepatoid adenocarcinoma.

From the Departments of *Nuclear Medicine and

Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.

Received for publication October 3, 2018; revision accepted February 2, 2019.

H.Y. and Y.H. contributed equally to this study.

Conflicts of interest and sources of funding: H.Y. was sponsored by a Young Scholar Grant from the National Natural Science Foundation of China (81501500). None declared to all other authors.

Correspondence to: Hongcheng Shi, MD, PhD, Department of Nuclear Medicine, Zhongshan, Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China. E-mail:

Online date: April 15, 2019

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