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A Critical Assessment of the Linear No-Threshold Hypothesis

Its Validity and Applicability for Use in Risk Assessment and Radiation Protection

Siegel, Jeffry A., PhD*; Brooks, Antone L., PhD; Fisher, Darrell R., PhD; Zanzonico, Pat B., PhD§; Doss, Mohan, PhD; O'Connor, Michael K., PhD; Silberstein, Edward B., MA, MD**; Welsh, James S., MS, MD††; Greenspan, Bennett S., MD, MS‡‡

doi: 10.1097/RLU.0000000000002613
Original Articles

The Society of Nuclear Medicine and Molecular Imaging convened a task group to examine the evidence for the risk of carcinogenesis from low-dose radiation exposure and to assess evidence in the scientific literature related to the overall validity of the linear no-threshold (LNT) hypothesis and its applicability for use in risk assessment and radiation protection. In the low-dose and dose-rate region, the group concluded that the LNT hypothesis is invalid as it is not supported by the available scientific evidence and, instead, is actually refuted by published epidemiology and radiation biology. The task group concluded that the evidence does not support the use of LNT either for risk assessment or radiation protection in the low-dose and dose-rate region.

From the *Nuclear Physics Enterprises, Marlton, NJ;

Washington State University, Kennewick;

Versant Medical Physics and Radiation Safety, Richland, WA;

§Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY;

Diagnostic Imaging, Fox Chase Cancer Center, Philadelphia, PA;

Department of Radiology, Mayo Clinic, Rochester, MN;

**Departments of Radiology and Medicine (emeritus), University of Cincinnati Medical Center, Cincinnati, OH;

††Department of Radiation Oncology, Stritch School of Medicine Loyola University-Chicago, Maywood, IL; and

‡‡North Augusta, SC.

Received for publication February 20, 2019; revision accepted March 27, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Bennett S. Greenspan, MD, MS, 150 River Club Lane, North Augusta, SC 29841. E-mail:

Online date: May 17, 2019

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