Persistent hyperinsulinemic hypoglycemia in adults is most commonly caused by insulinomas, which pose a diagnostic challenge to physicians, surgeons, and radiologists and require multimodality imaging for precise localization and staging. PET tracers such as 18F-FDOPA and glucagon-like peptide 1 receptor analogs have been used for imaging insulinomas. Glucagon-like peptide 1 receptor analogs have recently shown promising results in preoperative localization of these tumors, as all insulinomas express glucagon-like peptide 1 receptors. 68Ga-DOTA-Exendin PET and MRI done in the present case helped in precise localization and management of the culprit lesion, whereas contrast-enhanced CT and 18F-FDOPA PET failed to do so.
From the Departments of *Nuclear Medicine,
∥Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Received for publication November 10, 2018; revision accepted March 30, 2019.
Conflicts of interest and sources of funding: none declared.
Correspondence to: Anish Bhattacharya, DNB, PhD, Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. E-mail: email@example.com.
Online date: May 17, 2019