Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

68Ga-DOTA-Exendin PET-MRI Fusion Imaging in a Case of Insulinoma

Sood, Apurva, MD*; Basher, Rajender Kumar, MD*; Kang, Mandeep, MD; Shukla, Jaya, PhD*; Behera, Arunanshu, MS; Walia, Rama, MD, DM§; Nada, Rithambhra, MD; Mittal, Bhagwant Rai, MD, DNB*; Bhattacharya, Anish, DNB, PhD*

doi: 10.1097/RLU.0000000000002620
Interesting Images

Persistent hyperinsulinemic hypoglycemia in adults is most commonly caused by insulinomas, which pose a diagnostic challenge to physicians, surgeons, and radiologists and require multimodality imaging for precise localization and staging. PET tracers such as 18F-FDOPA and glucagon-like peptide 1 receptor analogs have been used for imaging insulinomas. Glucagon-like peptide 1 receptor analogs have recently shown promising results in preoperative localization of these tumors, as all insulinomas express glucagon-like peptide 1 receptors. 68Ga-DOTA-Exendin PET and MRI done in the present case helped in precise localization and management of the culprit lesion, whereas contrast-enhanced CT and 18F-FDOPA PET failed to do so.

From the Departments of *Nuclear Medicine,


General Surgery,

§Endocrinology, and

Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Received for publication November 10, 2018; revision accepted March 30, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Anish Bhattacharya, DNB, PhD, Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. E-mail:

Online date: May 17, 2019

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.