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Synchronous Paraganglioma Masquerading as 68Ga-PSMA PET/CT–Avid Metastasis in Carcinoma Prostate—How Specific Is 68Ga-PSMA PET/CT?

Tyagi, Shantanu, Mch(Urology)*; Singh, Shrawan Kumar, Mch(Urology); Narain, Tushar Aditya, Mch(Urology)*; Singh, Harmandeep, MD, Nuclear Medicine; Kumar, Rajender, MD, Nuclear Medicine; Vadi, Shelvin Kumar, MD, Nuclear Medicine

doi: 10.1097/RLU.0000000000002589
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We present a case of biopsy-proven prostatic adenocarcinoma with a tracer-avid left paravertebral location at D4 to D5 vertebrae, suggestive of metastasis. However, in view of uncommon location of single-site metastasis at paravertebral region with no tracer-avid regional lymphadenopathy, image-guided biopsy was done, which was suggestive of paraganglioma. 68Ga-PSMA is known to have variable tracer avidity in multiple nonprostatic benign as well as malignant lesions, and our case adds to the list of nonspecific uptake by this once considered “specific” to prostate PET radiotracer.

From the *PGIMER, and

Departments of Urology, and

Nuclear Medicine, PGIMER, Chandigarh, India.

Received for publication January 9, 2019; revision accepted March 5, 2019.

Conflicts of intrest and sources of funding: none declared.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent was obtained from all individual participants included in the study.

Consent for publication was obtained for every individual data included in the study.

Correspondence to: Shrawan Kumar Singh, Mch(Urology), Advanced Urology Ward, Nehru Hospital PGIMER, No. 26, Level 2, B Block, Chandigarh 160012, India. E-mail:

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