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Postchemotherapy Histiocyte-Rich Pseudotumor of the Spleen Simulating Residual Disease in a Patient With Non-Hodgkin Lymphoma on FDG PET/CT

Hod, Nir, MHA, MD*; Lantsberg, Sophie, MD*; Anconina, Reut, MD*; Levin, Daniel, MD*; Nalbandyan, Karen, MD; Levi, Itai, MD

doi: 10.1097/RLU.0000000000002568
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A 64-year-old man was treated with multiagent chemotherapy owing to high-grade non-Hodgkin lymphoma presenting as a bulky disease involving the spleen. Interim and posttreatment sequential FDG PET/CT scans revealed a residual splenic mass showing markedly intense FDG uptake suspected of a residual viable lymphoma. To definitely decide about the appropriate treatment, a laparoscopic splenectomy was performed. Histopathologic specimen was compatible with the rare diagnosis of postchemotherapy histiocyte-rich pseudotumor of the spleen, a potential pitfall simulating viable disease on FDG PET/CT.

From the *Institute of Nuclear Medicine and Molecular Imaging,

Institute of Pathology, and the

Department of Hematology, Soroka University Medical Center, Beer-Sheva, Israel. Affiliated to Ben Gurion University of the Negev, Faculty of Health Sciences.

Received for publication December 3, 2018; revision accepted February 18, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Nir Hod MHA, MD, Institute of Nuclear Medicine and Molecular Imaging, Soroka University Medical Center, POB 151, Beer-Sheva, Israel. E-mail:

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