A 64-year-old man was treated with multiagent chemotherapy owing to high-grade non-Hodgkin lymphoma presenting as a bulky disease involving the spleen. Interim and posttreatment sequential FDG PET/CT scans revealed a residual splenic mass showing markedly intense FDG uptake suspected of a residual viable lymphoma. To definitely decide about the appropriate treatment, a laparoscopic splenectomy was performed. Histopathologic specimen was compatible with the rare diagnosis of postchemotherapy histiocyte-rich pseudotumor of the spleen, a potential pitfall simulating viable disease on FDG PET/CT.
From the *Institute of Nuclear Medicine and Molecular Imaging,
†Institute of Pathology, and the
‡Department of Hematology, Soroka University Medical Center, Beer-Sheva, Israel. Affiliated to Ben Gurion University of the Negev, Faculty of Health Sciences.
Received for publication December 3, 2018; revision accepted February 18, 2019.
Conflicts of interest and sources of funding: none declared.
Correspondence to: Nir Hod MHA, MD, Institute of Nuclear Medicine and Molecular Imaging, Soroka University Medical Center, POB 151, Beer-Sheva, Israel. E-mail: email@example.com.