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Pneumonitis Related to Melanoma Immunotherapy

García-Gómez, Francisco Javier, MD, MSc*; Álamo-de la Gala, María Carmen, MSc; de la Riva-Pérez, Pablo Antonio, MSc*; de la Cruz-Merino, Luis, PhD; de la Cinta Calvo-Morón, María, MSc*

doi: 10.1097/RLU.0000000000002549
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Several regimens of immunotherapy have recently proven successful for multiple cancers, due to increased survival and quality of life. Rarely, immunotherapy with anti-programmed cell death protein 1 and programmed death-ligand 1 antibodies across cancer may cause immune-related pulmonary toxicity, with a low overall incidence, being particularly low among patients with melanoma and highest among individuals with lung cancer. In this vein, pulmonary toxicity is staged at 4 degrees according to the severity of the clinic and radiological findings, and its management is based on suppression of immunotherapy and administration of glucocorticoids. We report a case of pulmonary toxicity related to melanoma immunotherapy observed by 18F-FDG PET/CT.

From the *Department of Nuclear Medicine and

Clinical Oncology Department, Virgen Macarena University Hospital, Seville, Spain.

Received for publication September 25, 2018; revision accepted February 6, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Francisco Javier García-Gómez, MD, MSc, Department of Nuclear Medicine, Virgen Macarena University Hospital, Avda. Dr. Fedriani 3, 41009, Seville, Spain. E-mail:

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