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Malignant Peripheral Nerve Sheath Tumor With Bilateral Adrenal Metastases

Role of 18F-FDG PET/CT in Response Assessment to Tyrosine Kinase Inhibitor and Liposomal Doxorubicin

Tripathy, Sarthak, MD*; Passah, Averilicia, MD*; Singhal, Abhinav, MD; Prashanth, Arun, MD*; Kumar, Rakesh, MD, PhD*

doi: 10.1097/RLU.0000000000002542
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MPNSTs (malignant peripheral nerve sheath tumors) are a highly malignant group of soft tissue sarcomas and carry a very poor prognosis. Metastasis to bilateral adrenal glands is very rare in such group of neoplasms. We discuss a case of 85-year-old man who was diagnosed with MPNST from prevertebral mass with metastases to bilateral adrenal glands and bone marrow from the beginning and role of serial 18F-FDG PET/CT scans in response assessment first to sunitinib (tyrosine kinase inhibitor) and then to liposomal doxorubicin.

From the *Department of Nuclear Medicine and PET-CT, All India Institute of Medical Sciences; and

Department of Nuclear Medicine and PET-CT, Institute of Liver and Biliary Sciences, New Delhi, India.

Received for publication January 21, 2019; revision accepted February 3, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Rakesh Kumar, MD, PhD, Diagnostic Nuclear Medicine Division, Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. E-mail:

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