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Giant Cell Tumor of Tendon Sheath Revealed on 68Ga-DOTA-TATE PET/CT in a Patient With Suspicious Tumor-Induced Osteomalacia

Jia, Chaoyi, MD*†; Shao, Fuqiang, MD*‡; Yang, Ming, MD§; Qin, Chunxia, MD, PhD*‡; Lan, Xiaoli, MD, PhD*‡

doi: 10.1097/RLU.0000000000002550
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Giant cell tumor of tendon sheath (GCTTS) is benign mesenchymal neoplasm, and it rarely induces hypophosphatemia. We report a 49-year-old woman with suspicious tumor-induced osteomalacia underwent 68Ga-DOTA-TATE PET/CT to identify potential causative tumor, which showed a hypermetabolic soft tissue nodule in the right foot. Pathology confirmed it as GCTTS following surgical resection. The patient's symptoms improved rapidly, and the serum phosphate normalized after surgery, which supports the diagnosis of tumor-induced osteomalacia. Our case showed GCTTS can be rich of somatostatin receptor and cause osteomalacia.

From the *Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and

The Second Clinical College, Tongji Medical College, Huazhong University of Science and Technology;

Hubei Key Laboratory of Molecular Imaging; and

§Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Received for publication January 26, 2019; revision accepted February 6, 2019.

Conflicts of interest and sources of funding: This work was supported by the Key Project of Hubei Province Technical Innovation Special Funding (no. 2017ACA182) and the Clinical Research Physician Program of Tongji Medical College, Huazhong University of Science and Technology (no. 5001530008). None declared to all authors.

Correspondence to: Xiaoli Lan, MD, PhD, Department of Nuclear Medicine, Wuhan Union Hospital, No. 1277 Jiefang Ave, Wuhan 430022, China. E-mail: LXL730724@hotmail.com.

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