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The Racoon Eye Sign in the Investigation of Dementia Using 18F-Florbetaben

Ordidge, Katherine, MBBS, FRCR, PhD; Gandy, Nemi, MBBS, FRCR; Arshad, Mubarik, MBBS, MRCP, FRCR; Win, Zarni, MBBS, MRCP, FRCR

doi: 10.1097/RLU.0000000000002502
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Differentiating Alzheimer disease (AD) from other forms of cognitive impairment and from normal aging can be challenging. As a consequence, the diagnosis of AD can be delayed, often occurring too late for meaningful intervention. The role of β-amyloid plaques in the pathogenesis of AD provides a target for highly sensitive and specific image quantification of amyloid plaque burden using β-amyloid PET (18F-florbetaben). Here we present the case of a 77-year-old woman with increasing memory impairment and striking white matter changes on MRI, with the “racoon eye” sign on 18F-florebetaben PET imaging.

From the Nuclear Medicine Department, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom.

Received for publication November 12, 2018; revision accepted January 9, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Zarni Win, MBBS, MRCP, FRCR, Nuclear Medicine Department, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom. E-mail:

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