We report a case of splenic marginal zone B-cell lymphoma discovered in a 73-year-old man with cold agglutinin disease. PET/CT revealed splenomegaly with focally intense uptake of 18F-FDG and diffusely increased bone marrow uptake, which was considered to be secondary to hemolytic anemia. Splenectomy was performed. The histopathology of the spleen showed splenic marginal zone B-cell lymphoma with partial splenic infarction, which correlated with the area of focal intense FDG uptake. Depending on the time since onset, splenic infarctions can present as focal FDG accumulation.
From the *Department of Radiology, Shiga General Hospital;
†Division of PET Imaging, Shiga Medical Center Research Institute; and
Departments of ‡Hematology and
§Pathology, Shiga General Hospital, Moriyama, Japan.
Received for publication December 19, 2018; revision accepted January 24, 2019.
Conflicts of interest and sources of funding: none declared.
Correspondence to: Ryusuke Nakamoto, MD, PhD, Shiga General Hospital, 5-4-30, Moriyama, Moriyama, Shiga 524-8524, Japan. E-mail: email@example.com.