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Prostate Cancer Pulmonary Metastasis Presenting as a Ground-Glass Pulmonary Nodule on 68Ga-PSMA-11 PET/CT

Lubin, David J., MD, PhD*; Holden, Stuart B., MD; Rettig, Matthew B., MD; Reiter, Robert E., MD; King, Christopher R., MD, PhD†‡; Lee, Jay M., MD§; Wallace, Dean W., MD; Calais, Jeremie, MD, MSc*†

doi: 10.1097/RLU.0000000000002499
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68Ga–prostate-specific membrane antigen 11 (PSMA) PET/CT imaging accurately depicts metastatic prostate adenocarcinoma (PCa). Pulmonary metastases of PCa are often overlooked on follow-up imaging in patients after initial treatment and following androgen deprivation therapy. Here we present a rare case of biopsy-proven PCa pulmonary metastasis with a ground-glass appearance. The increased PSMA expression and the evolving CT features of the solid component of the ground-glass nodule detected by PSMA PET/CT imaging led to surgical resection and PET/CT-guided therapy.

From the *Ahmanson Translational Theranostics Division, Department of Molecular & Medical Pharmacology;

Institute of Urologic Oncology, Department of Urology;

Department of Radiation Oncology;

§Division of Thoracic Surgery, Department of Surgery; and

Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA.

Received for publication November 14, 2018; revision accepted December 25, 2018.

Conflicts of interest and sources of funding: J.C. is the recipient of a grant from the Philippe Foundation Inc (New York). None declared to all other authors.

Author’s contributions: Conception and design: S.H., R.R., M.R., C.K., and J.C.; Acquisition of data: D.L., J.M.L., C.K., W.D.W., and J.C.; Analysis and interpretation of data: S.H., R.R., M.R., C.K., W.D.W., and J.C.; Drafting/revising of the manuscript critically for important intellectual content: D.L., S.H., R.R., M.R., J.M.L., C.K., W.D.W., and J.C.; Final manuscript approval for submission and publication: D.L., S.H., R.R., M.R., J.M.L., C.K., W.D.W., and J.C.

Correspondence to: Jeremie Calais, MD, MSc, Ahmanson Translational Imaging and Nuclear Medicine Division, Department of Molecular & Medical Pharmacology, University of California, Los Angeles, Peter Norton Medical Bldg, 200 Medical Plaza, Suite B-114-51, Los Angeles, CA 90095. E-mail: jcalais@mednet.ucla.edu.

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