We present a case of oropharyngeal squamous cell carcinoma (SCC) of the tongue base incidentally detected on 18F-fluciclovine PET/CT. A 79-year-old man with history of locally advanced prostate cancer (Gleason score 4 + 5 = 9; cT2cN1M0) previously treated with androgen deprivation therapy (luprolide + bicalutamide) presented with a slowly rising serum prostate-specific antigen over 3 years, concerning for recurrent disease. 18F-fluciclovine PET/CT, obtained to identify potential sites of recurrence, demonstrated prostate bed uptake with possible left seminal vesicle involvement. Additionally, an exophytic, tracer-avid right tongue base mass was incidentally noted and later confirmed to be p16+ SCC on biopsy.
From the *Division of Nuclear Medicine, Department of Radiology and Biomedical Imaging,
†Department of Pathology,
‡Division of Hematology/Oncology, Department of Medicine, and
§Division of Head and Neck Surgical Oncology, Department of Otolaryngology – Head and Neck Surgery, University of California San Francisco, San Francisco, CA.
Received for publication December 13, 2018; revision accepted January 12, 2019.
Conflicts of interest and sources of funding: none declared.
Correspondence to: Robert R. Flavell, MD, PhD, Assistant Professor in Residence, Division of Nuclear Medicine, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St, Suite 350, Box 0946, San Francisco, CA 94143. E-mail: Robert.Flavell@ucsf.edu.