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18F-FDG PET/CT Findings in Disseminated Genital Herpes in an Immunocompetent Patient With Anaplastic Lymphoma Kinase Rearranged Advanced Nonsmall Cell Lung Cancer

Dejanovic, Danijela, MD*; Amtoft, Annemarie Gjelstrup, MD*; Sørensen, Jens Benn, MD, DMSc, MPA; Pøhl, Mette, MD, PhD

doi: 10.1097/RLU.0000000000002523
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We present the PET/CT findings of extensive disseminated genital herpes simplex virus infection in a 29-year-old woman known with disseminated anaplastic lymphoma kinase–mutated nonsmall lung cancer. PET/CT revealed extensive involvement of the outer and inner genitalia, multiple lymph nodes extending from the porta hepatis to the groins, and involvement of the liver. Disseminated herpes simplex virus infection is well described in neonates and immunocompromised individuals but very rare in immunocompetent adults as was the case with this patient.

From the Departments of *Clinical Physiology, Nuclear Medicine and PET, and

Oncology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.

Received for publication October 24, 2018; revision accepted January 23, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Danijela Dejanovic, MD, Blegdamsvej 9 2100, Copenhagen, Denmark. E-mail:

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