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Tumor Identification of Less Aggressive or Indolent Lymphoma With Whole-Body 11C-Acetate PET/CT

Tsuchiya, Junichi, MD*; Yamamoto, Masahide, MD, PhD; Bae, Hyeyeol, MD*; Oshima, Takumi, MD*; Yoneyama, Tomohiro, MD, PhD*; Miura, Osamu, MD, PhD; Tateishi, Ukihide, MD, PhD*

doi: 10.1097/RLU.0000000000002464
Original Articles

Purpose The aim of this study was to investigate the diagnostic performance of whole-body [11C]acetate PET/CT in less aggressive or indolent lymphomas, wherein [18F]FDG PET/CT would exhibit limited sensitivity.

Methods Between September 2016 and May 2018, we prospectively evaluated 17 patients (9 men, 8 women; mean age [range], 71 [45–87] years) with pathologically proven less aggressive or indolent lymphomas according to Non-Hodgkin's Lymphoma Classification Project, using both [18F]FDG PET/CT and [11C]acetate PET/CT (performed on the same day). Detected nodal lesions were recorded according to the Ann Arbor classification. Extranodal (EN) lesions were also evaluated. We compared whole-body lesion detection between [18F] FDG PET/CT and [11C]acetate PET/CT using the McNemar test.

Results In all patients, significantly more nodal and EN lesions were detected using [11C]acetate PET/CT than [18F]FDG PET/CT (nodal: 84 vs 64 regions; P < 0.001; EN: 26 vs 19 regions, P = 0.039). Bone lesions were detected in 8 and 5 patients using [11C]acetate PET/CT and [18F]FDG PET/CT, respectively (P = 0.25). Among the 14 patients (82.4%) who underwent bone marrow biopsy, bone marrow involvement was detected with sensitivities of 100% (6/6 patients) and 80% (5/6 patients) using [11C]acetate PET/CT and [18F]FDG PET/CT, respectively. Multiple areas of focal uptake in the spleen of 1 patient were exhibited on [18F]FDG PET/CT but not [11C]acetate PET/CT.

Conclusions [11C]acetate PET/CT exhibited greater sensitivity than [18F]FDG PET/CT for lesion detection in patients with less aggressive or indolent lymphomas, thus promising applicability as a physiological tracer in the study of such lesions.

From the Departments of *Diagnostic Radiology and Nuclear Medicine, and

Hematology, Tokyo Medical and Dental University, Tokyo, Japan.

Received for publication September 28, 2018; revision accepted December 2, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Junichi Tsuchiya, MD, Diagnostic Radiology Department, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8510 Tokyo, Japan. E-mail:

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