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Atypical Presentation of T-Cell Large Granular Lymphocytic Leukemia Mimicking Pleural Malignancy on 18F-FDG PET/CT

Senthil, Raja MD*; Visakh R., Arun MD*; Pratap, Thara MD; Mahadevan, Pushpa MD; Gangadharan, V P MD§

doi: 10.1097/RLU.0000000000002425
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T-cell large granular lymphocytic leukemia is a rare form of leukemia, caused by clonal proliferation of cytotoxic T-cells, characterized by modest lymphocytosis and cytopenias of other lineage with hepatosplenomegaly and relatively rare lymph nodal involvement. Involvement of other organs is extremely rare. It is predominantly an indolent disease and most of patients remain asymptomatic for a long period. We present a rare case of aggressive form (CD56 positive) of large granular lymphocytic leukemia with atypical presentations mimicking pleural malignancy on 18F-FDG PET/CT.

From the Departments of *Nuclear Medicine and PET/CT

Radiology

Pathology

§Medical Oncology, VPS Lakeshore Hospital, Kochi, India.

Received for publication September 1, 2018; revision accepted November 1, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Raja Senthil, MD, Department of Nuclear Medicine and PET/CT, VPS Lakeshore Hospital, Maradu, Nettoor (P.O.), Kochi, Kerala 682040, India. E-mail: senthilrajapgi@yahoo.com.

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