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68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue

Ferraro, Daniela A. MD*; Rupp, Niels J. MD; Donati, Olivio F. MD; Messerli, Michael MD*; Eberli, Daniel MD, PhD§; Burger, Irene A. MD*

doi: 10.1097/RLU.0000000000002473
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Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a 68Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry.

From the *Department of Nuclear Medicine, University Hospital Zürich, University of Zürich

Department of Pathology and Molecular Pathology, University Hospital and University of Zürich

Institute of Diagnostic and Interventional Radiology, University Hospital Zürich

§Department of Urology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.

Received for publication August 14, 2018; revision accepted December 16, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Daniela A. Ferraro, MD, Department of Nuclear Medicine, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland. E-mail:

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