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68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue

Ferraro, Daniela A., MD*; Rupp, Niels J., MD; Donati, Olivio F., MD; Messerli, Michael, MD*; Eberli, Daniel, MD, PhD§; Burger, Irene A., MD*

doi: 10.1097/RLU.0000000000002473
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Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a 68Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry.

From the *Department of Nuclear Medicine, University Hospital Zürich, University of Zürich;

Department of Pathology and Molecular Pathology, University Hospital and University of Zürich;

Institute of Diagnostic and Interventional Radiology, University Hospital Zürich; and

§Department of Urology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.

Received for publication August 14, 2018; revision accepted December 16, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Daniela A. Ferraro, MD, Department of Nuclear Medicine, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland. E-mail:

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