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Parapharyngeal Ganglioneuroma Detected by 18F-FDG PET/CT in a Patient With Hodgkin Lymphoma

Yi, Wan-Ling, BS*; Chen, Tzu-Pai, BS*; Chiu, Nan-Tsing, MD; Liu, Chiang-Shin, DDS; Lin, Yu-Hsuan, MD§∥

doi: 10.1097/RLU.0000000000002444
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A 38-year-old woman with anterior mediastinal Hodgkin lymphoma underwent 18F-FDG PET/CT, revealing abnormal uptake at the left retrostyloid parapharyngeal space. After chemotherapy, follow-up PET/CT showed regression of previously avid lesions but not the left retropharyngeal mass. Subsequent MRI revealed findings suggestive of neurogenic tumor. Transoral biopsy revealed ganglioneuroma, which is uncommon in the parapharyngeal space, although usually of benign nature. This case therefore highlights the importance of PET/CT in both initial diagnostic screening for tumor development and posttreatment evaluation of ambiguous lesions.

From the *Medical College of National Cheng Kung University;

Departments of Nuclear Medicine, and

Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan;

§Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung; and

Departmentof Otolaryngology, Head and Neck surgery, National Defense Medical Center, Taipei, Taiwan.

Received for publication August 21, 2018; revision accepted November 26, 2018.

Conflicts of interest and sources of funding: none declared.

This manuscript is original and it, or any part of it, has not been previously published; nor is it under consideration for publication elsewhere.

Authors' contributions: Y.-H.L. had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Concept and design: W.-L.Y., Y.-H.L. Acquisition, analysis, or interpretation of data: W.-L.Y., T.-P.C., N.-T.C., C.-S.L., Y.-H.L. Drafting the manuscript: Y.-H.L., W.-L.Y., T.-P.C. Critical revision of the manuscript for important intellectual content: W.-L.Y., T.-P.C., N.-T.C., C.-S.L., Y.-H.L. Final approval: W.-L.Y., T.-P.C., N.-T.C., C.-S.L., Y.-H.L.

Correspondence to: Yu-Hsuan Lin, MD, Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Veterans General Hospital, No 386, Ta-Chung 1st Road, Kaohsiung City 813, Taiwan, Republic of China. E-mail: mdlinyh@gmail.com.

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