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Diffuse Skeletal Hemangiomatosis Mimicking Metastastic Disease on 18F-FDG PET/CT

Huang, Dong, MD*; Ou, Xiaohong, MD*; Ye, Yunxia, MD; Zhang, Wenjie, MD*

doi: 10.1097/RLU.0000000000002445
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Diffuse skeletal hemangiomatosis is a rare vascular proliferation disorder involving multiple bones and may be confused with metastatic bone malignancy. We present a case of a 53-year-old man suffering back and proximal right femur pain underwent 18F-FDG PET/CT scan. Multiple hypermetabolic lesions of bone were concerning for metastatic carcinoma. Since no primary malignancy was found, open biopsy was performed and histologic examination led to a diagnosis of diffuse skeletal angiomatosis. This case highlighted the importance of including diffuse skeletal hemangiomatosis in the differential diagnosis of multiple hypermetabolic skeletal lesions on 18F-FDG PET/CT.

From the Departments of *Nuclear Medicine and

Pathology, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan (610041), People’s Republic of China.

Received for publication August 30, 2018; revision accepted November 16, 2018.

Yunxia Ye and Wenjie Zhang contributed equally to this work and shared joint first authorship.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Xiaohong Ou, MD, Department of Nuclear Medicine, West China Hospital, Sichuan University, No.37, Guoxue, Alley, Chengdu 610041, People’s Republic of China. E-mail:

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