Diffuse skeletal hemangiomatosis is a rare vascular proliferation disorder involving multiple bones and may be confused with metastatic bone malignancy. We present a case of a 53-year-old man suffering back and proximal right femur pain underwent 18F-FDG PET/CT scan. Multiple hypermetabolic lesions of bone were concerning for metastatic carcinoma. Since no primary malignancy was found, open biopsy was performed and histologic examination led to a diagnosis of diffuse skeletal angiomatosis. This case highlighted the importance of including diffuse skeletal hemangiomatosis in the differential diagnosis of multiple hypermetabolic skeletal lesions on 18F-FDG PET/CT.
From the Departments of *Nuclear Medicine and
†Pathology, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan (610041), People’s Republic of China.
Received for publication August 30, 2018; revision accepted November 16, 2018.
Yunxia Ye and Wenjie Zhang contributed equally to this work and shared joint first authorship.
Conflicts of interest and sources of funding: none declared.
Correspondence to: Xiaohong Ou, MD, Department of Nuclear Medicine, West China Hospital, Sichuan University, No.37, Guoxue, Alley, Chengdu 610041, People’s Republic of China. E-mail: firstname.lastname@example.org.