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Two Cases of 188Re Microspheres for Inoperable Hepatocellular Carcinoma

Shukla, Jaya, PhD*; Kalra, Naveen, MD; Kumar, Rajender, MD*; Bhusari, Priya, PhD*; Chhabra, Anupriya, MSc*; Parmar, Madan, MSc*; Vatsa, Rakhee, PhD*; Singh, Harmandeep, MD*; Duseja, Ajay, MD, DM; Mittal, B. R., MD*

doi: 10.1097/RLU.0000000000002373
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Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. Often, patients present with inoperable and advanced disease. Selective internal radionuclide therapy offers prolonged survival and improved quality of life by delivering high radiation dose to the tumor with minimal complications. We report 2 inoperable cases of HCC treated with therapeutic dose of indigenously developed 188Re microspheres delivered to the hepatic lesions by transarterial catheterization. Follow-up CT revealed necrosis within the lesion, suggesting response to selective internal radionuclide therapy. 188Re microspheres may be a potential treatment option for inoperable HCC with or without portal vein thrombosis.

From the Departments of *Nuclear Medicine,

Radiodiagnosis & Imaging, and

Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Received for publication July 6, 2018; revision accepted October 2, 2018.

Conflicts of interest and sources of funding: Financial support was provided by the Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research Chandigarh, India. None declared to all authors.

Correspondence to: Jaya Shukla, PhD, Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012 India. E-mail: shuklajaya@gmail.com.

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