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Primary Diffuse Leptomeningeal Melanomatosis of Spine

18F-FDG PET Findings

Ayan, Asli, MD*; Akbulut, Aylin, MD; Deveci, Guzin, MD; Koca, Gokhan, MD

doi: 10.1097/RLU.0000000000002384
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Primary diffuse leptomeningeal melanomatosis is a rare variant of malignant melanoma of the central nervous system, arising from melanocytes of leptomeninges. It may involve leptomeninges and may invade brain superficially. The diagnosis of the disease with conventional imaging techniques is quite difficult. This case demonstrates the 18F-FDG uptake of primary diffuse leptomeningeal melanomatosis matching with MRI contrast enhancement regions particularly in the lower thoracic and superior lumbar region.

From the *Department of Nuclear Medicine, Gulhane School of Medicine University of Health Sciences,

Department of Nuclear Medicine, Ankara Application and Research Hospital, and

Department of Pathology, Gulhane School of Medicine, University of Health Sciences, Ankara, Turkey.

Received for publication July 26, 2018; revision accepted October 8, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Aylin Akbulut, MD, Department of Nuclear Medicine, University of Health Sciences, Ankara Application and Research Hospital, Ulucanlar St, 06340 Ankara, Turkey. E-mail:

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