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Juvenile Nasal Angiofibroma on 68Ga-PSMA PET/CT

Opening New Frontiers

Sakthivel, Pirabu, MS*; Prashanth, Arun, MD; Thakar, Alok, MS*; Kumar, Rajeev, PhD; Kumar, Rakesh, MD

doi: 10.1097/RLU.0000000000002387
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The prostate-specific membrane antigen (PSMA) is highly expressed in prostatic cancer. However, PSMA expression is also noted in various benign and malignant nonprostatic neoplasms in the endothelial cells of tumor-associated neovasculature. We performed 68Ga-PSMA PET/CT in a 14-year-old boy with juvenile nasal angiofibroma (JNA) to explore its theranostic potential. The scan revealed high uptake in the lesion. Performance of PSMA PET/CT in JNA opens up new frontiers with respect to radiological staging, early recurrence identification, and perhaps even radioligand therapy of residual/recurrent JNAs in the future.

From the Departments of *Otorhinolaryngology and Head and Neck Surgery, and

Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Received for publication September 24, 2018; revision accepted October 9, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Rakesh Kumar, MD, Division of Diagnostic Nuclear Medicine, Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. E- mail:

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