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Diffuse Large B-Cell Lymphoma Recurring as Neurolymphomatosis on FDG PET/CT

Ganeshalingam, Rueben, MBBS; Roach, Paul, MBBS, FRACP, FAANMS; Schembri, Geoffrey Paul, MBBS, FRACP, BSc

doi: 10.1097/RLU.0000000000002388
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Two patients with diffuse large B-cell lymphoma relapsing as neurolymphomatosis diagnosed on FDG PET/CT are presented. Both patients were treated initially with chemotherapy and had a complete metabolic response. Patient 1 represented with lower-limb pain. An FDG PET/CT demonstrated intense uptake throughout the sciatic nerves bilaterally extending distally with relapse confirmed on biopsy. Patient 2 represented to hospital with worsening mobility, neuropathic pain, and facial asymmetry. An FDG PET/CT demonstrated relapse within the spinal cord, left sciatic nerve, and facial nerve branches. Neurolymphomatosis is an uncommon finding on FDG PET/CT and can be the only site of relapse.

From the Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia.

Received for publication August 9, 2018; revision accepted October 9, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Rueben Ganeshalingam, MBBS, Nuclear Medicine, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia 2065. E-mail:

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