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A Mixed Variant of Castleman Disease Detected by Somatostatin Receptor Scintigraphy with 99mTc-HYNIC-TOC and 18F-FDG PET/CT

Pan, Qingqing, MD; Zhang, Xin, MD; Luo, Yaping, MD; Ma, Yanru, MD; Li, Fang, MD

doi: 10.1097/RLU.0000000000002411
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A 50-year-old woman was found with a hypervascular abdominal mass in the right lower quadrant in contrast-enhanced CT. Somatostatin receptor scintigraphy with 99mTc-HYNIC-TOC showed positivity of the abdominal mass and detected additional lesion with moderate increased radioactivity in the right axilla. In 18F-FDG PET/CT, both of the lesions were FDG-avid. A hypermetabolic node in the right supraclavicular fossa was also noted. The histopathological examination of the abdominal mass after surgical resection revealed Castleman disease, a mixed hyaline vascular and plasma cell variant. The right axillary and supraclavicular lesions were considered involvement of Castleman disease.

From the Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital; and Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, People’s Republic of China.

Received for publication September 23, 2018; revision accepted October 22, 2018.

Conflicts of interest and sources of funding: This work is supported by the CAMS Initiative for Innovative Medicine (CAMS-I2M, 2017-I2M-3-001). None declared to all authors.

Correspondence to: Yaping Luo, MD, Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital; Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Wangfujing, Dongcheng District, Beijing 100730, People’s Republic of China. E-mail: luoyaping@live.com.

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