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Idiopathic Inflammatory Myopathy and Antisynthetase Syndrome

Early Diagnosis by 99mTc-HDP Bone Scintigraphy

Fernández-Rodríguez, Paula, MD; Martín-Marcuartu, Juan José, MD; Jiménez-Hoyuela, Jose Manuel, MD, PhD

doi: 10.1097/RLU.0000000000002312
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We present a 44-year-old woman with scapular and pelvic muscle weakness, joint inflammation, and fever. Bone scintigraphy showed high uptake in proximal regions of upper and lower limbs, suspecting inflammatory myopathy and polyarticular damage. These features were the clue to request other complementary tests such as anti–aminoacyl-tRNA-synthetase antibodies and chest CT, which showed interstitial lung disease, defining an antisynthetase syndrome. Therefore, BS allows an earlier diagnosis of inflammatory muscle disease and to identify the optimal site for muscle biopsy. BS is an important step to reach a prompt diagnosis of antisynthetase syndrome for establishing an early treatment.

From the Department of Nuclear Medicine, Virgen del Rocío University Hospital, Seville, Spain.

Received for publication May 18, 2018; revision accepted September 2, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Paula Fernández-Rodríguez, MD, Nuclear Medicine Service, Virgen del Rocío University Hospital, Av. Manuel Siurot, 41013 Seville, Spain. E-mail:

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