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Gastric GIST Incidentally Detected on 68Ga-PSMA-PET/CT

Correlation Between Functional Imaging and Histology

Vaz, Sofia, MD; Oliveira, Carla, MD; Castanheira, Joana C., MD; Silva, Ângelo F., MD; Costa, Durval C., MD, MSc, PhD, FRCR

doi: 10.1097/RLU.0000000000002347
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Prostate-specific membrane antigen (PSMA) is specific for prostate cancer cells; nevertheless when finding uptake in abnormal locations for prostate cancer metastases, it is important to consider other hypothesis, including second cancers. There are several papers about PSMA expression in many different types of cancer, but few reported expression in gastrointestinal stromal tumors (GIST). In this case, we documented the GIST lesion not only by PET/CT but also by gastroscopy and histology. Additionally, PSMA immunochemistry was performed, showing PSMA expression in tumoral GIST cells (not in endothelial cells), evidencing a good correlation between PET/CT image and histology.

From the Department of Nuclear Medicine, Champalimaud Foundation, Lisbon, Portugal.

Received for publication May 30, 2018; revision accepted September 18, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Sofia Vaz, MD, Department of Nuclear Medicine, Champalimaud Foundation, Av. Brasília, 1400-038 Lisbon, Portugal. E-mail:

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