A 76-year-old man with biochemical failure after primary radiotherapy for prostate cancer had no malignant disease detected on 99mTc-MDP bone scan and diagnostic CT. Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein, is overexpressed in prostate cancer cells. The PSMA-targeted 18F-DCFPyL PET/CT demonstrated lymph node disease and photopenic defects in the left kidney associated with a cyst and biopsy-proven oncocytoma. Prostate-specific membrane antigen is expressed in the neovasculature of several solid tumors. It has been reported that PSMA expression is seen in approximately 50% of oncocytoma versus 76% of clear cell renal carcinomas. Biopsy confirmation is needed regardless of 18F-DCFPyL avidity.
From the *McMaster University, Hamilton, Ontario, Canada;
†Hanyang University College of Medicine, Seoul, South Korea;
‡University of British Columbia, Vancouver, British Columbia; and
§London Health Sciences Centre, Ontario, Canada.
Received for publication July 26, 2018; revision accepted August 22, 2018.
Conflicts of interest and sources of funding: none declared.
J.L. and R.X. contributed equally to this publication.
Correspondence to: Chun K. Kim, MD, Main Building (Bon-Gwan), Rm 403, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea. E-mail: firstname.lastname@example.org.