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18F-DCFPyL PET/CT in Oncocytoma

Li, Jeremy, BSc*; Xu, Richard, BSc*; Kim, Chun K., MD; Bénard, François, MD; Kapoor, Anil, MD*; Bauman, Glenn, MD§; Zukotynski, Katherine A., MD*

doi: 10.1097/RLU.0000000000002301
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A 76-year-old man with biochemical failure after primary radiotherapy for prostate cancer had no malignant disease detected on 99mTc-MDP bone scan and diagnostic CT. Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein, is overexpressed in prostate cancer cells. The PSMA-targeted 18F-DCFPyL PET/CT demonstrated lymph node disease and photopenic defects in the left kidney associated with a cyst and biopsy-proven oncocytoma. Prostate-specific membrane antigen is expressed in the neovasculature of several solid tumors. It has been reported that PSMA expression is seen in approximately 50% of oncocytoma versus 76% of clear cell renal carcinomas. Biopsy confirmation is needed regardless of 18F-DCFPyL avidity.

From the *McMaster University, Hamilton, Ontario, Canada;

Hanyang University College of Medicine, Seoul, South Korea;

University of British Columbia, Vancouver, British Columbia; and

§London Health Sciences Centre, Ontario, Canada.

Received for publication July 26, 2018; revision accepted August 22, 2018.

Conflicts of interest and sources of funding: none declared.

J.L. and R.X. contributed equally to this publication.

Correspondence to: Chun K. Kim, MD, Main Building (Bon-Gwan), Rm 403, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea. E-mail: chunkikim@hanyang.ac.kr.

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