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Chemokine Receptor 4 Expression in Primary Sjögren’s Syndrome

Cytawa, Wojciech, MD, PhD*†; Kircher, Stefan, MD, PhD; Schirbel, Andreas, Dr Rer. Nat. PhD*; Shirai, Takahiro§; Fukushima, Kazuhito, MD, PhD*; Buck, Andreas K., MD, PhD*; Wester, Hans-Jürgen, MD, PhD; Lapa, Constantin, MD, PhD*

doi: 10.1097/RLU.0000000000002258
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68Ga-pentixafor is a novel radioligand of C-X-C motif chemokine receptor 4. A 55-year-old woman with a history of primary Sjögren’s syndrome underwent 68Ga-pentixafor PET/CT for staging of lymphoma originating from mucosa-associated lymphoid tissue. Whereas no lymphoma manifestation could be detected, imaging revealed bilateral intense radiotracer uptake in both parotid and submandibular salivary glands, consistent with inflammatory cell infiltration.

From the *Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany;

Department of Nuclear Medicine, Medical University of Gdańsk, Gdańsk, Poland;

Institute of Pathology, University of Würzburg, Comprehensive Cancer Center Mainfranken (CCCMF), Würzburg, Germany;

§Nagasaki University, School of Medicine, Nagasaki, Japan; and

Pharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.

Received for publication June 10, 2018; revision accepted July 17, 2018.

Conflicts of interest and sources of funding: H.-J.W. is founder and shareholder of Scintomics. All other authors have none declared.

Correspondence to: Wojciech Cytawa, MD, PhD, Department of Nuclear Medicine, Medical University of Gdańsk, Dębinki Str. 7, 80-952 Gdańsk, Poland. E-mail:

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