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68Ga–Prostate-Specific Membrane Antigen PET/CT and 18F-FDG PET/CT of Primary Signet Ring Cell Breast Adenocarcinoma

Parihar, Ashwin Singh, MBBS*; Mittal, Bhagwant Rai, MD, DNB*; Sood, Apurva, MD*; Basher, Rajender Kumar, MD*; Singh, Gurpreet, MS

doi: 10.1097/RLU.0000000000002265
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Primary signet ring cell adenocarcinoma of the breast is a rare neoplasm. Similar to other mucinous neoplasms, it has low FDG avidity and poor prognosis compared with the traditional ductal/lobular carcinomas. We present a case of a 40-year-old woman with signet ring cell adenocarcinoma and skeletal fluorosis showing higher uptake of 68Ga–prostate-specific membrane antigen in the primary lesion and the metastatic sites compared with 18F-FDG on PET/CT imaging. Additionally, diffuse increased prostate-specific membrane antigen uptake was noticed in the entire skeleton, likely due to skeletal fluorosis.

From the *Department of Nuclear Medicine & PET and

General Surgery Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Received for publication June 9, 2018; revision accepted July 22, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Bhagwant Rai Mittal, MD, DNB, Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. E-mail:

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