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Mazabraud’s Syndrome Mimicking Metastases on FDG PET/CT in a Patient With Colon Cancer

Mahajan, Sonia, MD*; Goel, Reema, MD*; Riedl, Christopher, MD*†; Ulaner, Gary A., MD, PhD*†

doi: 10.1097/RLU.0000000000002151
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Mazabraud’s, a syndrome consisting of fibrous dysplasia and soft tissue myxomas, is a rare disorder with less than 100 cases reported in the literature. Appearance of lesions in Mazabraud’s syndrome on FDG PET/CT scan in an oncological scenario can be misinterpreted as malignancy. We present the case of a 69-year-old woman, diagnosed with metastatic colon carcinoma and suspected osseous as well as soft tissue metastases, who was later found to have concomitant Mazabraud’s syndrome. This case describes the diagnostic dilemma associated with this unusual entity and importance of differentiating benign and malignant etiologies on FDG PET/CT scan.

From the *Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY; and

Department of Radiology, Weill Cornell Medical College, New York, NY.

Received for publication April 16, 2018; revision accepted April 20, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Gary A. Ulaner, MD, PhD, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 77, New York, NY 10065. E-mail: ulanerg@mskcc.org.

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