Secondary Logo

Institutional members access full text with Ovid®

Share this article on:

BRCA2 Mutation as a Possible Cause of Poor Response to 177Lu-PSMA Therapy

Ahmadzadehfar, Hojjat, MD, MSc*; Gaertner, Florian, MD*; Lossin, Philipp S., MD; Schwarz, Bettina, MD*; Essler, Markus, MD*

doi: 10.1097/RLU.0000000000002141
Interesting Images

We present the case of a 66-year-old man with castration-resistant prostate cancer, with an increasing prostate-specific antigen level, and a progressive disease during 177Lu-PSMA radionuclide therapy. Because the patient had a BRCA2 mutation, poly-ADP ribose polymerase inhibitor therapy was started. The patient showed a dramatic subjective and biological response to this therapy with a progression-free survival of 5 months.

From the *Department of Nuclear Medicine, University Hospital Bonn; and

Urological Center Bonn-Rhein-Sieg, Bonn, Germany.

Received for publication March 27, 2018; revision accepted April 7, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Hojjat Ahmadzadehfar, MD, MSc, Department of Nuclear Medicine, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. E-mail:

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.