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68Ga DOTA-Exendin PET/CT for Detection of Insulinoma in a Patient With Persistent Hyperinsulinemic Hypoglycemia

Parihar, Ashwin Singh, MBBS*; Vadi, Shelvin Kumar, MD*; Kumar, Rajender, MD*; Mittal, Bhagwant Rai, MD, DNB*; Singh, Harmandeep, MD*; Bal, Amanjit, MD; Walia, Rama, MD, DM; Shukla, Jaya, MSc, PhD*; Sinha, Saroj Kumar, MD, DM§

doi: 10.1097/RLU.0000000000002155
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Insulinomas are the most common functioning pancreatic neuroendocrine tumors and the leading cause of persistent hypoglycemia with hyperinsulinemia in adults. Glucagon-like-peptide-1 (GLP) receptor analogs are the latest agents being used in the detection of insulinomas, with initial reports suggesting high sensitivity due to universal GLP1 receptor expression on these tumors. PET/CT imaging in this patient using 68Ga DOTA-Exendin, a GLP receptor analog, proved useful for accurate localization of the culprit lesion, aiding in the definitive management of the patient.

From the Departments of *Nuclear Medicine and PET/CT,

Histopathology,

Endocrinology, and

§Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Received for publication April 3, 2018; revision accepted April 21, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Bhagwant Rai Mittal, MD, DNB, Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh-160012, India. E-mail: brmittal@yahoo.com.

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