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Temporal Uptake Patterns of 18F-Fluorocholine Among Hyperfunctioning Parathyroid Glands

Morland, David, MD, MSc*†‡; Richard, Capucine, MD§; Godard, François, MD*; Deguelte, Sophie, MD; Delemer, Brigitte, MD, PhD

doi: 10.1097/RLU.0000000000002132
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Optimal scan time of 18F-fluorocholine (FCH) PET/CT for localization of hyperfunctioning parathyroid glands is poorly documented. We report a small series of 9 histologically proven hyperfunctioning parathyroid gland with heterogeneous temporal uptake profile. Thirty-minute dynamic acquisition starting just after 18F-fluorocholine administration and delayed acquisition were recorded. Three different uptake patterns are seen (early washout, stable uptake, late increase) indicating the importance of an early (5–10 minutes) acquisition. A late acquisition (60 minutes) could be useful when the early acquisition is negative. No correlations were noted between uptake profile and histological or genetic results.

From the *Unité de Médecine Nucléaire, Institut Jean Godinot;

Laboratoire de Biophysique, UFR de Médecine,

CReSTIC (Centre de Recherche en Sciences et Technologies de l’Information et de la Communication), EA 3804, Université de Reims Champagne-Ardenne;

§Unité Thyroïde, Institut Jean Godinot;

Service de Chirurgie Viscérale et Endocrinienne, Hôpital Universitaire Robert Debré; and

Service d’Endocrinologie, Diabétologie et Nutrition, Hôpital Universitaire Robert Debré, Reims, France.

Received for publication January 4, 2018; revision accepted April 7, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: David Morland, MD, MSc, Unité de Médecine Nucléaire, Institut Jean Godinot, 1 Rue du Général Koenig, 51100 Reims, France. E-mail: david.morland@reims.unicancer.fr.

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