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Detection of Cerebrospinal Fluid Dissemination of Recurrent Glioblastoma Using TSPO-PET With 18F-GE-180

Unterrainer, Marcus, MD, MSc*; Fleischmann, Daniel F., MD, MSc†‡; Lindner, Simon, PhD*; Brendel, Matthias, MD*; Rupprecht, Rainer, MD§; Tonn, Joerg C., MD‡∥; Belka, Claus, MD†‡; Bartenstein, Peter, MD*‡; Niyazi, Maximilian, MD†‡; Albert, Nathalie L., MD*‡

doi: 10.1097/RLU.0000000000002113
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PET targeting the translocator protein (TSPO) represents an interesting approach for glioma visualization, as TSPO is highly expressed in tumor cells. We present a 32-year-old man with recurrent glioblastoma after multimodal treatment. PET with the novel TSPO ligand 18F-GE-180 was performed after reirradiation. Here, the previously reirradiated tumor showed a remaining circular TSPO expression. Moreover, cerebrospinal fluid dissemination was detected by a high focal uptake at the right lateral and at the fourth ventricle, whereas only a faint contrast enhancement was present in MRI. This case demonstrated the diagnostic potential of TSPO-PET for glioma imaging by visualizing even minimal disease burden.

From the Departments of *Nuclear Medicine, and

Radiation Oncology, University Hospital, LMU Munich, Munich;

German Cancer Consortium (DKTK), partner site Munich, and German Cancer Research Center (DKFZ), Heidelberg

§Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg; and

Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.

Received for publication January 23, 2018; revision accepted March 20, 2018.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Marcus Unterrainer, MD, MSc, Department of Nuclear Medicine, University Hospital, LMU Munich, Marchioninistr 15, 81377 Munich, Germany. E-mail:

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