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68Ga–Prostate-Specific Membrane Antigen PET/CT in Triple-Negative Breast Cancer

Passah, Averilicia, MD; Arora, Saurabh, MD; Damle, Nishikant Avinash, MD, DNB; Tripathi, Madhavi, MD; Bal, Chandrasekhar, MD; Subudhi, T. Kishan, MD; Arora, Geetanjali, PhD

doi: 10.1097/RLU.0000000000002071
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The prostate-specific membrane antigen (PSMA) is a transmembrane protein with elevated expression in prostate cancer cells. Breast cancer also shows PSMA expression. We present the case of a 30-year-old woman with triple-negative bilateral breast carcinoma who underwent bilateral mastectomy, chemotherapy, and radiotherapy. She developed a left chest wall and liver recurrence after primary therapy. Her recurrent disease was also triple-negative. In view of the known poor prognosis and very limited therapeutic options, we performed 68Ga-PSMA PET/CT scan to explore the possibility of PSMA-based therapy as a future option after exhausting standard-of-care treatments.

From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Received for publication February 11, 2018; revision accepted February 25, 2018.

Conflicts of interest and sources of funding: none declared.

Author Contributions: A.P.: manuscript preparation, literature search, patient management; S.A., M.T.: manuscript preparation, literature search, patient management; N.A.D.: manuscript preparation, literature search, manuscript review, patient management; C.B.: manuscript review, patient management; T.K.S.: scan acquisition, manuscript preparation; G.A.: manuscript preparation, literature search.

Correspondence to: Nishikant Avinash Damle, MD, DNB, Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. E-mail: nkantdamle@gmail.com.

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