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11C-4DST PET/CT Imaging of Cardiac Sarcoidosis

Comparison With 18F-FDG and Cardiac MRI

Hotta, Masatoshi, MD*; Minamimoto, Ryogo, MD, PhD*; Kubota, Shuji, MD; Awaya, Toru, MD; Hiroi, Yukio, MD, PhD

doi: 10.1097/RLU.0000000000002059
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A 75-year-old woman with a history of sarcoidosis presenting with low cardiac output and complete right bundle-branch block underwent 4′-[methyl-11C]-thiothymidine (4DST) PET/CT after cardiac MRI and FDG PET/CT for the evaluation of suspected cardiac sarcoidosis (CS) before treatment. Cardiac MRI revealed late gadolinium enhancement on the anterior-to-lateral and posterior wall, indicating CS. FDG uptake was shown on the anterior-to-lateral wall, but not on the posterior wall. In contrast, 4DST uptake was demonstrated on both anterior-to-lateral and posterior walls. Use of 4DST appears promising for detecting CS without dietary restriction, due to the lack of physiological uptake in myocardium.

From the Departments of *Nuclear Medicine, and †Cardiology, National Center for Global Health and Medicine, Tokyo, Japan.

Received for publication February 5, 2018; revision accepted February 10, 2018.

Conflicts of interest and sources of funding: This work was supported by a grant from the National Center for Global Health and Medicine (no. 29-2005 to Ryogo Minamimoto).

This work was approved by the National Center for Global Health and Medicine institutional review board, and written informed consent was obtained from the patient.

Correspondence to: Masatoshi Hotta, MD, Department of Nuclear Medicine, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162–8655, Japan. E-mail:

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