Clinical Significance of a Solitary Cold Thyroid Nodule in the Setting of Graves DiseaseAchong, Dwight, M., MDClinical Nuclear Medicine: January 2018 - Volume 43 - Issue 1 - p e27–e28 doi: 10.1097/RLU.0000000000001897 Interesting Images Abstract Author Information 123I-NaI thyroid uptake and scan in a 46-year-old woman with symptomatic hyperthyroidism demonstrated marked, diffusely increased uptake consistent with Graves disease, as well as a solitary hypofunctioning (“cold”) nodule. Pathologic evaluation following total thyroidectomy and selective neck dissection revealed invasive multifocal papillary thyroid carcinoma in a background of Graves disease and 5 of 36 lymph nodes positive for metastatic disease. This case serves as a reminder that when present a cold nodule in the setting of Graves disease warrants further evaluation for underlying malignancy. From the Nuclear Medicine Service, James A. Haley Veterans' Hospital & Clinics; and University of South Florida Morsani College of Medicine, Tampa, FL. Received for publication August 18, 2017; revision accepted October 26, 2017. Conflicts of interest and sources of funding: none declared. Correspondence to: Dwight M. Achong, MD, Nuclear Medicine (115), James A. Haley Veterans' Hospital, 13000 Bruce B. Downs Blvd, Tampa, FL 33612. E-mail: firstname.lastname@example.org. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.