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Multiorgan Involvement of Chemotherapy-Induced Sarcoidosis Mimicking Progression of Lymphoma on FDG PET/CT

Sanan, Prateek, MD; Lu, Yang, MD, PhD

doi: 10.1097/RLU.0000000000001735
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A 35-year-old woman with biopsy-proven recurrent Hodgkin lymphoma in the neck lymph nodes received salvage chemotherapy of brentuximab/insulin growth factor-methotrexate. Although the patient continued doing well clinically with no constitutional symptoms or significant laboratory abnormalities following the second recurrence, subsequent FDG PET CT examinations over the next 2 years revealed multiple new FDG-avid foci including lymph nodes above/below the diaphragm, liver, spleen, lungs, and bone. An alternate diagnosis of chemotherapy-induced sarcoidosis was suggested and confirmed on both bone marrow and right inguinal node biopsy.

From the Department of Radiology, University of Illinois Hospital & Health Sciences System, Chicago, IL.

Received for publication March 16, 2017; revision accepted May 8, 2017.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Yang Lu, MD, PhD, Department of Radiology (M/C 931), University of Illinois Hospital & Health Sciences System, 1740 W Taylor St, Chicago, IL 60612. E-mail: yang.lu630@gmail.com.

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