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FDG PET/CT Findings of Nodular Sclerosis–Subtype Classic Hodgkin Lymphoma Presented as Mediastinal Nodal Lesions at Onset But as Predominant Osseous Disease at Relapse

Zheng, Kun, MD*; Zhuang, Hongming, MD, PhD, FACNM

doi: 10.1097/RLU.0000000000001664
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Nodular sclerosis–subtype classic Hodgkin lymphoma in general manifests as bulky mediastinal lymphadenopathy but very rarely involves bones. We report FDG PET/CT findings of a 19-year-old man with pathology-proven, nodular sclerosis–type classic Hodgkin lymphoma. His initial FDG PET/CT scan at the diagnosis showed only hypermetabolic lymphadenopathy in the mediastinum. However, the FDG PET/CT acquired when the disease recurred 20 months later showed predominant osseous disease without additional nodal lesions outside the mediastinum.

From the *Department of Nuclear Medicine, Peking Union Hospital, Beijing, China; and †Department of Radiology, The Children’s Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA.

Received for publication February 27, 2017; revision accepted February 28, 2017.

K.Z. was partially supported by grants from Beijing Natural Science Foundation (7174338), National Natural Science Foundation of China (81601551), and PUMCH Science Fund of Key Projects for Junior Faculty (pumch-2016-1.4).

Correspondence to: Kun Zheng, MD, Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, No 1 Shuaifuyuan, Wangfujing St, Dongcheng District, Beijing 100730, People’s Republic of China. E-mail:

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