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90Y Liver Radioembolization Imaging Using Amplitude-Based Gated PET/CT

Osborne, Dustin R. PhD, DABSNM; Acuff, Shelley CNMT, RT(R), CT; Neveu, Melissa MD; Kaman, Austin; Syed, Mumtaz MD, PhD; Fu, Yitong MD

doi: 10.1097/RLU.0000000000001613
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The usage of PET/CT to monitor patients with hepatocellular carcinoma following 90Y radioembolization has increased; however, image quality is often poor because of low count efficiency and respiratory motion. Motion can be corrected using gating techniques but at the expense of additional image noise. Amplitude-based gating has been shown to improve quantification in FDG PET, but few have used this technique in 90Y liver imaging. The patients shown in this work indicate that amplitude-based gating can be used in 90Y PET/CT liver imaging to provide motion-corrected images with higher estimates of activity concentration that may improve posttherapy dosimetry.

From the Department of Radiology, University of Tennessee Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN.

Received for publication October 24, 2016; revision accepted January 15, 2017.

Conflicts of interest and sources of funding: The University of Tennessee maintains ongoing collaborations with Siemens Medical Solutions USA, Inc. D.R.O. and S.A. occasionally provide expert testimonial to Siemens Medical Solutions USA, Inc. The other authors have none declared.

Correspondence to: Dustin R. Osborne, PhD, DABSNM, Molecular Imaging & Translational Research Program, University of Tennessee Medical Center, 1924 Alcoa Hwy, Knoxville, TN 37920. E-mail:

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