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18F-NaF and 18F-FDG PET/CT in Gorham-Stout Disease

Papadakis, Georgios Z. MD; Millo, Corina MD; Bagci, Ulas PhD; Blau, Jenny MD; Collins, Michael T. MD

doi: 10.1097/RLU.0000000000001369
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Gorham-Stout disease (GSD) is an extremely rare skeletal disorder of unknown etiology characterized by benign proliferation of vascular or lymphatic channels, leading to progressive bone resorption. We report on a patient diagnosed with GSD affecting the right scapula and the right ribs, who underwent PET/CT scans using 18F-FDG and 18F-NaF. The remnant upper portion of the affected scapula did not show 18F-FDG uptake but demonstrated markedly increased 18F-NaF activity. Furthermore, intense 18F-NaF activity was seen on the right posterior ribs, which were actively being resorbed, suggesting the potential application of 18F-NaF-PET/CT imaging in GSD diagnosis and follow-up.

From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda; †Division of Nuclear Medicine, RAD&IS, Clinical Center, National Institutes of Health, Bethesda, MD; ‡Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida, Orlando, FL; §National Institute of Child Health and Human Development, National Institutes of Health, Bethesda; and ∥Craniofacial and Skeletal Diseases Branch, National Institutes of Dental and Craniofacial Research, Bethesda, MD.

Received for publication May 4, 2016; revision accepted July 22, 2016.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Michael T. Collins, MD, Skeletal Clinical Studies Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bldg 30, Room 228 MSC 4320, Bethesda MD 20892–4320. E-mail:

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