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ACR–ASNR Practice Parameter for Brain PET/CT Imaging Dementia

Frey, Kirk A., MD, PhD; Lodge, Martin A., PhD; Meltzer, Carolyn Cidis, MD, FACR; Peller, Patrick J., MD; Wong, Terence Z., MD, PhD; Hess, Christopher P., MD, PhD; Petrella, Jeffrey R., MD; Sair, Haris I., MD; Subramaniam, Rathan M., MD, PhD, MPH

doi: 10.1097/RLU.0000000000001037
Practice Guidelines

This practice parameter is for both FDG and amyloid brain PET or PET/computed tomography (CT) for patients with cognitive decline, and has been developed collaboratively by the American College of Radiology (ACR) and the American Society for Neuroradiology (ASNR). It is estimated that the number of people with dementia, 36.5 million worldwide in 2010, will increase to 65.7 million in 2030 and to 115 million in 2050. Four primary neurodegenerative etiologies of dementia have been defined: Alzheimer disease (AD), vascular dementia, frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). Alzheimer disease is the most common form of dementia, accounting for approximately 60%–80% of all cases. Indications for FDG and amyloid brain PET and qualifications for personnel are discussed in this practice parameter.

From the *Department of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor, MI; †Outpatient Center, Johns Hopkins University, Baltimore, MD; ‡Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA; §Eka Medical Center, Jakarta, Indonesia; ∥UNC Department of Radiology, Chapel Hill, NC; ¶Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA; **Division of Neuroradiology, Department of Radiology, Duke University Medical Center, Durham, NC; ††Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine; and ‡‡Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institution, Baltimore, MD.

Received for publication August 4, 2015; revision accepted August 20, 2015.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Rathan Subramaniam, MD, PhD, MPH, MClinEd, FACNM, FRANZCR, MRSNZ, Russell H Morgan Department of & Radiological Sciences, The Johns Hopkins School of Medicine and the Department of Health Policy and Management, The Johns Hopkins Bloomberg School of Public Health, 601 N. Caroline St/JHOC 3235, Baltimore, MD. E-mail:

Practice parameters and technical standards are published annually with an effective date of October 1 in the year in which amended, revised, or approved by the ACR Council. For practice parameters and technical standards published before 1999, the effective date was January 1 following the year in which the practice parameter or technical standard was amended, revised, or approved by the ACR Council.

Development chronology for this practice parameter: 2015 (Resolution 21).

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