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Diffuse 18F-FDG Muscle Uptake in Trichinella spiralis Infection

Deroose, Christophe M., PhD, MD*; Van Weehaeghe, Donatienne, MD*; Tousseyn, Thomas, PhD, MD; Van Rompuy, Anne-Sophie, MD; Vanderschueren, Steven, PhD, MD; Blockmans, Daniel, PhD, MD; Gheysens, Olivier, PhD, MD*

doi: 10.1097/RLU.0000000000000933
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Two patients were referred to our emergency department with myalgia, fever, general malaise, eosinophilia, and elevated serum levels of creatine kinase and troponin T. 18F-FDG PET/CT scan was performed showing a diffuse and homogenous moderately elevated glucose uptake in all muscle groups. Trichinella spiralis infection was confirmed by a muscle biopsy and detection of trichinella antibodies. The muscle biopsy was taken in the left quadriceps because of equal involvement of the skeletal muscles. The differential diagnosis of diffuse 18F-FDG muscle uptake should include trichinella infection, in particular, in the presence of infectious symptoms, eosinophilia, and biochemical signs of muscle damage.

From the Departments of *Nuclear Medicine, †Pathology, and ‡Internal Medicine, University Hospitals Leuven, Leuven, Belgium.

Received for publication January 21, 2015; revision accepted June 9, 2015.

Christophe M. Deroose, PhD, MD, and Donatienne Van Weehaeghe contributed equally to this study.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Christophe M. Deroose, PhD, MD, Department of Nuclear Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. E-mail:

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