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Epiglottic Squamous Cell Carcinoma Showing Unexpected 18F-FDOPA Uptake on PET/CT Investigation

Dietemann, Sebastien, MD*; Debry, Christian, MD, PhD; Onea, Aline, MD; Namer, Izzie Jacques, MD, PhD; Imperiale, Alessio, MD, PhD

doi: 10.1097/RLU.0000000000000818
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We report the unexpected findings of 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET/CT performed in a patient with a history of ileal carcinoid. A focally increased 18F-FDOPA uptake was detected in the left side of the epiglottis corresponding to a laryngeal squamous cell carcinoma. Interestingly, uptake of 3-O-methyl-6-18F-fluoro-l-dihydroxyphenylalanine, a metabolite of 18F-FDOPA, has been previously reported in both squamous cell carcinoma cell lines and the corresponding mouse tumor xenograft models. Although 18F-FDOPA is mainly used in patients with neuroendocrine tumors, 18F-FDOPA is not a neuroendocrine tumor–specific radiotracer.

From the Departments of *Biophysics and Nuclear Medicine, †Otolaryngology and Maxillofacial Surgery, and ‡Pathology, University Hospitals of Strasbourg; and §ICube, University of Strasbourg/CNRS (UMR 7357) and FMTS, Faculty of Medicine, Strasbourg, France.

Received for publication September 25, 2014; revision accepted March 9, 2015.

Conflicts of interest and sources of funding: none declared.

Reprints: Alessio Imperiale, MD, PhD, Service de Biophysique et de Médecine Nucléaire, Hôpital Universitaire de Hautepierre, 1, Avenue Molière, 67098 Strasbourg Cedex, France. E-mail:

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